[P1-127] Guillain-Barré Syndrome (GBS) of Chinese children in Hong Kong: A retrospective study focusing on subtype diagnosis, management and outcome
A retrospective study to evaluate the incidence, clinical profile, investigation findings, intervention required and clinical outcome of different subtypes of Guillain-Barré Syndrome in children in Hong Kong with admission to public hospitals between 2000 and 2015. Outcomes were determined by systematic review of medical records. A total of 48 cases were identified in 6 hospital clusters. The annual incidence was estimated to be 0.99 per 100000 population in the age group below 18 years of age. Electrophysiological studies confirmed 64.6% (31 patients) had acute inflammatory demyelinating polyradiculoneuropathy (AIDP), eight patients had acute motor axonal neuropathy (AMAN), eight patients had Miller-Fisher syndrome (MF), and one had acute motor and sensory axonal neuropathy (ASMAN). Prodromal illness was a common finding in 73% of patients (21 upper respiratory tract, 8 gastrointestinal tract, and 6 with other symptoms). Autonomic dysfunction occurred in 14.6% (7 patients) with hypertension being the commonest. Intravenous immunoglobulin was the most frequent treatment modality (81.3%). Plasmapheresis was given to 2, and oral prednisolone was given in 1 patient as adjunct. Forty percent (19 patients) needed intensive care support. Intensive care admission was significantly associated with the need of ventilator support (p=0.01). Use of ventilator support was significantly associated with more acute and the total number of bed days (p=0.009 and 0.005 respectively). Most affected children (81%) could be discharged from acute bed within 28days, and 81.3% had a complete recovery back to the premorbid state. Of the 11 children tested for the antiganglioside antibody, five (45.4%) were positive for anti-GQ1b.