Metal Homeostasis

[O-01] Dysregulation of Streptococcus pneumoniae Zinc Homeostasis Breaks Ampicillin Resistance in a Pneumonia Infection Model

*Stephanie Neville¹, Erin B Brazel², Aimee Tan¹, Amy R Iverson³, Saumya R Udagedara⁴, Bliss A Cunningham¹, Mwilye Sikanyika⁴, David M. P De Oliveira⁵, Bernhard Keller⁵, Lisa Bohlmann⁵, Ibrahim M El-deep⁶, Katherine Ganio¹, Bart A Eijkelkamp², Alastair G McEwan⁵, Mark von Itzstein⁶, Megan J Maher⁴, Mark J Walker⁵, Jason W Rosch³, Christopher A McDevitt¹ (1. Department of Microbiology and Immunology, The University of Melbourne, Melbourne, VIC, Australia, 2. Department of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, Australia, 3. Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, USA , 4. School of Chemistry and the Bio21 Institute, The University of Melbourne, Melbourne, VIC, Australia, 5. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia, 6. Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia)