[P26-1] P26-1: Anticonvulsant drugs

[P26-1-7] A population pharmacokinetic-pharmacodynamic analysis of valproic acid in pediatric patients with epilepsy

Kazuma Iwashita¹, Junji Saruwatari², Madoka Sugita³, Hiroo Nakashima⁴, Naoki Ogusu⁵, Masatsugu Shimomasuda⁶, Kentaro Oniki⁷, Takateru Ishitsu⁸ (1.Kumamoto University, 2.Kumamoto University, 3.Kumamoto University, 4.Kumamoto University, 5.Kumamoto University, 6.Kumamoto University, 7.Kumamoto University, 8. Kumamoto University)

キーワード：valproic acid, genetic polymorphisms, pharmacokinetics, pharmacodynamics, nonlinear mixed-effects model