[S-12] S-12: TDM for central nervous system drugs

[S-12-5] Neonatal PBPK modeling of morphine disposition with OCT1 transporter developmental expression

Chie Emoto¹, David Hahn², Alexander A. Vinks³, Tsuyoshi Fukuda⁴ (1.Cincinnati Children's Hospital Medical Center, 2.Cincinnati Children's Hospital Medical Center, 3.Cincinnati Children's Hospital Medical Center, 4.Cincinnati Children's Hospital Medical Center)

キーワード：Neonates, Ontogeny, OCT1 transporter, PBPK modeling, Morphine