[HIRANUMA-10] Assessment of bone ingrowth into porous nickel titanium dental implants through three-dimensional radiography and histology
[Abstract]
Porous Nickel Titanium (Porous-NiTi) dental implant represents a novel design aimed at improving clinical outcomes and expediting osseointegration. This study aimed to assess and compare bone response and bone-implant contact percentage (BIC%) at the peri-implant interface of Porous-NiTi implants and commercially available dense titanium (Dense-Ti) dental implants, utilizing micro-computed tomography (MicroCT) and histological analysis. Twelve dental implants, six Porous-NiTi, and six Dense-Ti, were inserted into the distal metaphysis of femoral bones in twelve New Zealand white rabbits. After a 12-week healing period, the animals were euthanized, and bone-implant interface samples were collected. MicroCT analysis evaluated BIC% in both 2D (BIC-2D) and 3D (BIC-3D), alongside other bone parameters (BS, BV, TV, and i.S). Subsequently, histological analysis was conducted to determine BIC% (BIC-histology), with light microscopy used to examine osseointegration and bone ingrowth on implant surfaces. Compared to Dense-Ti implants, Porous-NiTi dental implants exhibited significantly higher values for BS, BV, TV, i.S, and BIC-histology percentage (P<0.05). Histologically, both implant surfaces demonstrated a close relationship with bone tissue. Under higher magnification, new bone formation was observed in the pores of the Porous-NiTi implant, while the Dense-Ti implant displayed close adaptation to its flat surface. MicroCT and histological analyses revealed that Porous-NiTi implants had a higher BIC% (BIC-2D, BIC-3D, and BIC-histology) compared to Dense-Ti dental implants. These findings suggest that Porous-NiTi dental implants may achieve osseointegration comparable to Dense-Ti implants, potentially leading to enhanced implant stability through increased BIC.
トピックス
●Dental Implant
●Porous Implant
●Osseointegration
Porous Nickel Titanium (Porous-NiTi) dental implant represents a novel design aimed at improving clinical outcomes and expediting osseointegration. This study aimed to assess and compare bone response and bone-implant contact percentage (BIC%) at the peri-implant interface of Porous-NiTi implants and commercially available dense titanium (Dense-Ti) dental implants, utilizing micro-computed tomography (MicroCT) and histological analysis. Twelve dental implants, six Porous-NiTi, and six Dense-Ti, were inserted into the distal metaphysis of femoral bones in twelve New Zealand white rabbits. After a 12-week healing period, the animals were euthanized, and bone-implant interface samples were collected. MicroCT analysis evaluated BIC% in both 2D (BIC-2D) and 3D (BIC-3D), alongside other bone parameters (BS, BV, TV, and i.S). Subsequently, histological analysis was conducted to determine BIC% (BIC-histology), with light microscopy used to examine osseointegration and bone ingrowth on implant surfaces. Compared to Dense-Ti implants, Porous-NiTi dental implants exhibited significantly higher values for BS, BV, TV, i.S, and BIC-histology percentage (P<0.05). Histologically, both implant surfaces demonstrated a close relationship with bone tissue. Under higher magnification, new bone formation was observed in the pores of the Porous-NiTi implant, while the Dense-Ti implant displayed close adaptation to its flat surface. MicroCT and histological analyses revealed that Porous-NiTi implants had a higher BIC% (BIC-2D, BIC-3D, and BIC-histology) compared to Dense-Ti dental implants. These findings suggest that Porous-NiTi dental implants may achieve osseointegration comparable to Dense-Ti implants, potentially leading to enhanced implant stability through increased BIC.
トピックス
●Dental Implant
●Porous Implant
●Osseointegration