[HIRANUMA-12] Brain mechanisms of mastication in patients with temporomandibular disorders
[Abstract]
With an annual incidence rate of 3.9%, temporomandibular disorders (TMD) stand out as one of the most prevalent diseases of orofacial pain. Patients with TMD commonly report facial discomfort, restricted jaw mobility, and eating difficulty. Nevertheless, the clinical symptoms of TMD vary considerably among patients. While some individuals manage to cope adequately with the discomfort, others endure excruciating pain and may even be limited to consuming soft foods. Previous studies have focused on the major symptoms of TMD, namely, pain and masticatory dysfunction. Neuroimaging evidence has suggested that brain structure and function play a key role in pain and mastication. However, brain mechanisms underlying the association between pain and mastication in TMD have remained unexplored. The integrated pain adaptation model provides insight into how cognitive functions influence the perception and tolerance of pain. Within this framework, we analyzed the brain regions associated with orofacial pain and mastication with neuroimaging meta-analysis and found the anterior insula, a critical region for integrating cognitive, emotional, and sensory input, may play a critical role in TMD-related pain and masticatory dysfunction. Furthermore, by assessing patients’ masticatory performance, we quantified the functional limitations of patients and identified brain regions associated with masticatory dysfunction in TMD patients.
トピックス
●temporomandibular disorders
●mastication
●neuroimaging
With an annual incidence rate of 3.9%, temporomandibular disorders (TMD) stand out as one of the most prevalent diseases of orofacial pain. Patients with TMD commonly report facial discomfort, restricted jaw mobility, and eating difficulty. Nevertheless, the clinical symptoms of TMD vary considerably among patients. While some individuals manage to cope adequately with the discomfort, others endure excruciating pain and may even be limited to consuming soft foods. Previous studies have focused on the major symptoms of TMD, namely, pain and masticatory dysfunction. Neuroimaging evidence has suggested that brain structure and function play a key role in pain and mastication. However, brain mechanisms underlying the association between pain and mastication in TMD have remained unexplored. The integrated pain adaptation model provides insight into how cognitive functions influence the perception and tolerance of pain. Within this framework, we analyzed the brain regions associated with orofacial pain and mastication with neuroimaging meta-analysis and found the anterior insula, a critical region for integrating cognitive, emotional, and sensory input, may play a critical role in TMD-related pain and masticatory dysfunction. Furthermore, by assessing patients’ masticatory performance, we quantified the functional limitations of patients and identified brain regions associated with masticatory dysfunction in TMD patients.
トピックス
●temporomandibular disorders
●mastication
●neuroimaging