[ISL] オーラルヘルス研究における異分野融合型研究から実装へ
[Abstract]
Upon detection of a disease through epidemiological studies, researchers in a variety of disciplines initiate more studies in order to understand how to treat the disease. Basic scientists elucidate the biological mechanisms at the cellular level and in animal models. Based on those findings, interventions are then developed and tested in human clinical trials (Phases I, II, and III), followed by implementation research. Clinical and translational research begins with clinical trials to determine the efficacy of the intervention, followed by effectiveness research, and then implementation studies. For example in geroscience research, with aging now framed as telomere shortening and exacerbation of inflammation, investigators have been carrying out basic biological and animal experiments; clinical research has just begun on those efforts to delay, reverse, or cure diseases associated with aging.
As described above, translational research can be carried out in a multidisciplinary way, but it can also involve interactive and dynamic collaborative research programs and teams. In this presentation, I will discuss the translational research environment, emphasizing stakeholders, providers, and patients, exploring specialized fields, and addressing the development of human resources with a translational mindset.
トピックス
●Translational research
●Epidemiology
●Clinical trials
Upon detection of a disease through epidemiological studies, researchers in a variety of disciplines initiate more studies in order to understand how to treat the disease. Basic scientists elucidate the biological mechanisms at the cellular level and in animal models. Based on those findings, interventions are then developed and tested in human clinical trials (Phases I, II, and III), followed by implementation research. Clinical and translational research begins with clinical trials to determine the efficacy of the intervention, followed by effectiveness research, and then implementation studies. For example in geroscience research, with aging now framed as telomere shortening and exacerbation of inflammation, investigators have been carrying out basic biological and animal experiments; clinical research has just begun on those efforts to delay, reverse, or cure diseases associated with aging.
As described above, translational research can be carried out in a multidisciplinary way, but it can also involve interactive and dynamic collaborative research programs and teams. In this presentation, I will discuss the translational research environment, emphasizing stakeholders, providers, and patients, exploring specialized fields, and addressing the development of human resources with a translational mindset.
トピックス
●Translational research
●Epidemiology
●Clinical trials