[17a-418-1~10] 3.8 光計測技術・機器

▲ [17a-418-9] Cavity Ring-Down Spectroscopy for ¹⁴C Isotope Analysis of Biomedical Samples

〇(P)Sonnenschein Volker Thomas¹、Terabayashi Ryohei¹、Tomita Hideki¹、Hyashi Noriyoshi¹、Kato Shusuke¹、Jin Lei¹、Yamanaka Masahito¹、Nishizawa Norihiko¹、Sato Atsushi²、Nozawa Kohei²、Hashizume Kenta²、Oh-hara Toshinari²、Iguchi Tetsuo¹ (1.Nagoya Univ.、2.ADME & Tox. Research Inst., Sekisui Medical, Tokai, Ibaraki)

キーワード：molecular spectroscopy, cavity, 14C

High sensitivity techniques such as Accelerator Mass spectrometry are commonly used for detection of the radioisotope ¹⁴C. In the environment, its abundance is typically at the ppt level, however in medical samples, where it is used as tracer isotope to study the metabolism of subjects or other biological processes, the abundance can be significantly higher. Detection may then be performed by application of optical methods such as Cavity Ring-Down Spectroscopy (CRDS), thus providing a more compact and inexpensive solution as well as possibilities for in-field measurements.
We have built a compact CRDS system working in the Mid-infrared and show first results of spectroscopy of ¹⁴CO₂ in biomedical samples (plasma / urine).