Symposium

[Japanese session] Microtubule Dynamics and Higher Biological Functions: Toward Understanding Pathogenesis and Pathophysiology

Tue. Jun 28, 2022 9:30 AM - 12:00 PM Venue D (Tougen)

Organizers: Masami Yamada (University of Fukui), Gohta Goshima (Nagoya University)

Microtubules, which are subject to drastic spatiotemporal regulation, are involved in diverse and important cellular functions such as division, transport, polarity, migration, and morphological maintenance. In this symposium, we would like to discuss molecular regulatory mechanisms related to microtubules, diseases and developmental abnormalities caused by their dysfunction across organism (cell) species and tissues, especially neurological and psychiatric diseases in relation to nuclear and axonal transport, and neuronal migration.

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opening remarks (9:30 AM - 9:32 AM)

9:32 AM - 9:54 AM

[1D-102] Cystic kidney caused by disfunction of the microtubule minus-end regulator CAMSAP3

*Mika Toya¹, Masatoshi Takeichi², Masamitsu Sato³ (1. Waseda Univ. Global Center for Science and Engineering, 2. RIKEN BDR, 3. Waseda Univ. Sch. of Advanced Science and Engineering)

9:54 AM - 10:16 AM

[1D-103] Microtubules- and small GTPases-mediated regulation of cortical neuronal migration

*Takeshi Kawauchi¹ (1. Laboratory of Molecular Life Science, Institute of Biomedical Research and Innovation, FBRI)

10:16 AM - 10:29 AM

[1D-104] Identification of the anterograde organelle-transporting kinesin in plant

*Mari Yoshida¹, Gohta Goshima² (1. Graduate School of Science, Nagoya University, 2. Sugashima Marine Biological Laboratory, Nagoya University)

10:29 AM - 10:42 AM

[1D-105] Live cell imaging analysis of the self-organizing process for the intracellular coordination of airway multiple cilia

*Gen Shiratsuchi¹, Satoshi Konishi², Tomoki Yano³, Hiroka Kashihara¹, Shogo Nakayama⁴, Tatsuya Katsuno⁵, Elisa Herawati⁶, Shimpei Gotoh ⁷, Gen Kondoh⁸, Hitomi Watanabe⁸, Atsushi Tamura^1,9, Sachiko Tsukita¹ (1. Advanced Comprehensive Research Organization (ACRO), Teikyo University, 2. Department of Medicine, Duke University, 3. School of Medicine, Keio University, 4. RIKEN Center for Biosystems Dynamics Research (BDR), 5. Graduate School of Frontier Biosciences, Osaka University, 6. Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret, 7. Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 8. Institute for Life and Medical Sciences, Kyoto University, 9. Department of Pharmacology, Teikyo University School of Medicine)

10:42 AM - 11:04 AM

[1D-106] A novel neuronal function of mouse KPNA1/importin alpha 1 in axonal transport and neuronal migration.

*Katsutoshi Mizuno¹, Masaki Sugahara^1,2, Ryota Kato^1,2, Hirotaka Nomiya¹, Yoichi Miyamoto³, Masahiro Oka³, Takatoshi Hikida⁴, Takafumi Itoh⁵, Satoshi Fujita², Masami Yamada¹ (1. Univ. of Fukui School of Medical Sciences, 2. Univ. of Fukui School of Engineering, 3. National Institutes of Biomedical Innovation, Health, and Nutrition, 4. Osaka Univ. Institute for Protein Research , 5. Fukui Prefectural Univ. Depart. of Bioscience and Biotechnology)

11:04 AM - 11:26 AM

[1D-107] Cryo-electron tomography revealed that Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrate

*Hiroshi Yamaguchi¹, Motohiro Morikawa¹, Masahide Kikkawa¹ (1. The University of Tokyo, Graduate School of Medicine)

11:26 AM - 11:48 AM

[1D-108] Dynamic interplay of cytoskeletal motors during neuronal migration in the developing brain

*Mineko Kengaku¹, Naotaka Nakazawa¹, You Kure Wu¹, Gianluca Grenci² (1. Kyoto University, 2. National University of Singapore)

closing remarks (11:48 AM - 12:00 PM)