[P-1-088] High resolution OGSE DTI of cerebellar white matter in ex vivo mouse brain
In the past few years oscillating gradient spin-echo diffusion-tensor imaging (OGSE DTI) has been applied to measure changes to the apparent diffusion tensor (ADT) of brain tissue as a function of the frequency of the motion-probing gradients (MPGs) [1-4]. Most of these studies have been performed on ex vivo brain tissue (mouse [1], monkey [3] and human[4]) with just the one study of in vivo rat brain [2]. The study of ex vivo mouse brain was the first to demonstrate that increasing the MPG frequency strongly enhanced the mean diffusivity (MD) in the cerebellar granule cell layer (CBGr) of the cerebellum. There was also a much weaker increase for the cerebellar molecular layer (CBML). However, no data was presented for the cerebellar white matter (CBWM), which is odd because investigating the diffusion characteristics of white matter is one of the most prominent activities of diffusion-weighted MRI. The present study was performed to address this omission and report the first quantitative OGSE DTI measurements for mouse CBWM.1. Aggarwal et al, MRM 67:98-109 (2012); 2. Kershaw et al, NeuroImage 70:10-20 (2013); 3. Lundell et al, Proc ISMRM, 2073 (2013); 4. Aggarwal et al, Proc ISMRM, 838 (2013).