^○Joshua Eric Cramlett ¹, Melinda Manuel ¹, Erica Pierce ¹, Rondga Xu ², Dan Kassel ³, Donavon Mc Conn ¹ (1.Takeda California, 2.ACEA Biosciences, 3.SciAnalytical Strategies)

^○Tsutomu Nagata (Medicinal Chemistry Function, Asubio Pharma CO.,LTD.)

^○Harutoshi Kato (DMPK Research Laboratory, Mitsubishi Tanabe Pharma Corporation)

^○Koichi Handa ¹, Shuichi Hirono ² (1.Drug Safety, Metabolism and Pharmacokinetics Department, Research Laboratories, Toyama Chemical Co., Ltd., 2.Laboratory of Physical Chemistry for Drug Design, Department of Pharmaceutical Sciences, School of Pharmcay, Kitazato University)

^○Teruki Honma , Hitomi Yuki (Structure-based Molecular Design Team, RIKEN Center for Life Sclence Technologies)