A clinical drug interaction study using hepatic OATPs/CYP3A dual substrates: analysis of the rate-determining process based on the extended clearance concept

Takashi Yoshikado

Presentation information

Oral Presentation

2．Drug Interaction

Thu. Nov 12, 2015 10:40 AM - 11:30 AM Room E (2Ｆ Zuiun)

Chair:Masato Chiba (Pharmacokinetics Research Laboratories, Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., LTD.), Masahiro Iwaki (Division of Biopharmaceutics, Department of Pharmacy, Faculty of Pharmacy, Kinki University)

[O2-2] A clinical drug interaction study using hepatic OATPs/CYP3A dual substrates: analysis of the rate-determining process based on the extended clearance concept

^○Takashi Yoshikado ¹, Sawako Furihata ², Hanano Terashima ³, Takeshi Nakayama ³, Keiko Ishigame ¹, Kazunobu Tsunemoto ¹, Kazuya Maeda ³, Hiroyuki Kusuhara ³, Kenichi Furihata ², Yuichi Sugiyama ¹ (1.Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, 2.P-One Clinic, Keikokai Medical Corporation, 3.Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

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