[1Da09-12] PST

[1Da09] Damage to nucleic acids and cellular response induced by cold atmospheric pressure plasma irradiation

*Hirofumi Kurita¹ (1. Toyohashi University of Technology)

Recent progress in biological applications of cold atmospheric pressure plasma shows that the biological effects are mainly due to oxidative reactions induced by reactive species produced by exposure to the plasma. It is generally accepted that oxidative stress eventually causes damage to nucleic acids; therefore, nucleic acids are an essential biomolecular target for investigating the effects of plasma exposure. We have developed novel methodologies to assess the damage to nucleic acids and combined them with synthetic cell models. We also reported that plasma irradiation induces chemical modification of DNA bases as well as strand breaks. Furthermore, up-regulation of the DNA repair process in the plasma-irradiated cells was also observed.