2023年日本表面真空学会学術講演会

講演情報

ポスター発表

[2P01-53] Poster Presentation

2023年11月1日(水) 17:00 〜 18:30 ポスター (1階)

[2P51] The role of curcumin tautomerization in the disassembly of pentameric amyloid β42 oligomers

Atsuya Matsui1, Jean Pierre Bellier2, *Koutaro Fujii1, Takafumi Ishibe3, Yoshiaki Nakamura3, Hiroyasu Taguchi4, Nobuyasu Naruse1, Yutaka Mera1 (1. Department of Fundamental Bioscience, Shiga University of Medical Science, 2. Department, Brigham and Women’s Hospital, 3. Graduate School of Engineering Science, Osaka University, 4. Kyoto Womens’ University)

Alzheimer’s disease is characterized by amyloid-β peptide (Aβ) accumulation, initiating neurodegeneration. Pathogenic Aβ42 oligomers (oAβ42) drive the disease, emphasizing the significance of their investigation. Atomic force microscopic imaging revealed that curcumin and its derivatives with tautomerization play a role in disassembling oAβ42, in contrast to control derivatives that lack tautomerization. Molecular dynamics simulations supported our experimental findings. When curcumin and its derivatives with tautomerism bind to the hydrophobic region of oAβ42, the keto-form changes to the enol-form. This transformation causes conformational changes, leading to shifts in potential energy. Tautomerism allows curcumin to act as a torsional molecular spring, ultimately pulling apart the intermolecular space of the pentameric oAβ42.

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