2018年5月26日(土) 08:00 〜 10:00 第9会場 (ロイトン札幌2F リージェント・ホール)

座長：山中 宏二（名古屋大学環境医学研究所病態神経科学分野）, 井口 洋平（名古屋大学医学部神経内科）

Many neurodegenerative diseases share a common pathological feature: the deposition of amyloid-like fibrils composed of misfolded proteins. A wealth of evidence has emerged within the last decade suggests that these proteins may spread intercellularly and encourage the propagation of neurodegeneration toward the neighboring cells. Subsequent studies in cell and animal models revealed that protein misfolds including alpha-synuclein, tau and TDP-43 can propagate from cell-to-cell, and region-to-region in the brain through direct neuroanatomical connections. The transfer of the prionoid proteins between cells could therefore be a target for novel disease-modifying therapies. To make this scenario more convincing, we will invite five speakers with known expertise in this area to share the cutting-edge knowledge about the pathomechanistic basis of prionoid-spreading phenomenon.