[HT-01-1] α-シヌクレインおよびそれを超えて: パーキンソン病の神経変性の真犯人を探せ!_序論

徳田隆彦 (京都府立医科大学　分子脳病態解析学)

α-Synuclein is a primary component of Lewy bodies, and mutations / overexpression of it cause Parkinson’s disease (PD). Besides, Braak and colleagues identified Lewy pathologies, namely α-synuclein deposition, in various regions of human brains, and demonstrated the temporal sequence of α-synuclein pathologies that emerge in the brains of PD. However, the relationship between α-synuclein deposition and neuronal dysfunction / neuronal death and underlying mechanisms connecting them are still unclear. Is α-synuclein a true culprit of neurodegeneration in PD? If so, what are the precise molecular mechanisms involved with the neurotoxicity of α-synuclein? What other factors contribute to neurodegeneration in PD? Now it is high time that we should know the details molecular mechanisms involved with neurodegeneration in PD. Does α-Synuclein itself cause neurodegeneration or need other factors, namely α-synuclein and beyond?

[HT-01-2] α-Synucleinからはじまる神経毒性メカニズム

菅野直人 (東北大学病院神経内科)

α-Synuclein is a primary component of Lewy bodies, and mutations / overexpression of it cause Parkinson’s disease (PD). Besides, Braak and colleagues identified Lewy pathologies, namely α-synuclein deposition, in various regions of human brains, and demonstrated the temporal sequence of α-synuclein pathologies that emerge in the brains of PD. However, the relationship between α-synuclein deposition and neuronal dysfunction / neuronal death and underlying mechanisms connecting them are still unclear. Is α-synuclein a true culprit of neurodegeneration in PD? If so, what are the precise molecular mechanisms involved with the neurotoxicity of α-synuclein? What other factors contribute to neurodegeneration in PD? Now it is high time that we should know the details molecular mechanisms involved with neurodegeneration in PD. Does α-Synuclein itself cause neurodegeneration or need other factors, namely α-synuclein and beyond?

[HT-01-3] 局所単独あるいは多巣性のレヴィ小体病には軸索の高度分岐という共通の構造背景がある

内原俊記^1,2 (1.新渡戸記念中野総合病院神経内科・脳神経研究室, 2.東京医科歯科大学　脳神経病態学)

α-Synuclein is a primary component of Lewy bodies, and mutations / overexpression of it cause Parkinson’s disease (PD). Besides, Braak and colleagues identified Lewy pathologies, namely α-synuclein deposition, in various regions of human brains, and demonstrated the temporal sequence of α-synuclein pathologies that emerge in the brains of PD. However, the relationship between α-synuclein deposition and neuronal dysfunction / neuronal death and underlying mechanisms connecting them are still unclear. Is α-synuclein a true culprit of neurodegeneration in PD? If so, what are the precise molecular mechanisms involved with the neurotoxicity of α-synuclein? What other factors contribute to neurodegeneration in PD? Now it is high time that we should know the details molecular mechanisms involved with neurodegeneration in PD. Does α-Synuclein itself cause neurodegeneration or need other factors, namely α-synuclein and beyond?

[HT-01-4] Molecular mechanisms of selective neuronal vulnerability in PD and α-synuclein

James D. Surmeier (Feinberg School of Medicine Northwestern University)

α-Synuclein is a primary component of Lewy bodies, and mutations / overexpression of it cause Parkinson’s disease (PD). Besides, Braak and colleagues identified Lewy pathologies, namely α-synuclein deposition, in various regions of human brains, and demonstrated the temporal sequence of α-synuclein pathologies that emerge in the brains of PD. However, the relationship between α-synuclein deposition and neuronal dysfunction / neuronal death and underlying mechanisms connecting them are still unclear. Is α-synuclein a true culprit of neurodegeneration in PD? If so, what are the precise molecular mechanisms involved with the neurotoxicity of α-synuclein? What other factors contribute to neurodegeneration in PD? Now it is high time that we should know the details molecular mechanisms involved with neurodegeneration in PD. Does α-Synuclein itself cause neurodegeneration or need other factors, namely α-synuclein and beyond?

[HT-01-5] Distinct aggregation patterns of alpha-synuclein in PD and MSA: Is it all about strains?

Wassilios Meissner^1,2,3 (1.Université de Bordeaux, Institut des Maladies Neurodégénératives, France, 2.Service de Neurologie, CHU Bordeaux, France, 3.Dept. Medicine, University of Otago, and New Zealand Brain Research Institute, New Zealand)

α-Synuclein is a primary component of Lewy bodies, and mutations / overexpression of it cause Parkinson’s disease (PD). Besides, Braak and colleagues identified Lewy pathologies, namely α-synuclein deposition, in various regions of human brains, and demonstrated the temporal sequence of α-synuclein pathologies that emerge in the brains of PD. However, the relationship between α-synuclein deposition and neuronal dysfunction / neuronal death and underlying mechanisms connecting them are still unclear. Is α-synuclein a true culprit of neurodegeneration in PD? If so, what are the precise molecular mechanisms involved with the neurotoxicity of α-synuclein? What other factors contribute to neurodegeneration in PD? Now it is high time that we should know the details molecular mechanisms involved with neurodegeneration in PD. Does α-Synuclein itself cause neurodegeneration or need other factors, namely α-synuclein and beyond?

セッション情報