[S-16-1] THE HISTORY AND EVOLUTION OF NEUROMYELITIS OPTICA SPECTRUM DISORDERS

Brian G. Weinshenker (Dept of Neurology, Mayo Clinic Rochester)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

[S-16-2] From the viewpoint of pathological study in MS

河内泉 (新潟大学医歯学総合病院脳研究所神経内科学分野)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

[S-16-3] 日本におけるMS研究の臨床および疫学的観点から

宮本勝一 (近畿大学病院神経内科)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

[S-16-4] Neuromyelitis optica : Taiwanese exprience

Jen Jen Su (Department of Neurology, National Taiwan University hospital)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

[S-16-5] NMOSDをAQP4抗体/MOG抗体関連疾患や多発性硬化症の病理学的研究の立場から考える

三須建郎 (東北大学病院神経内科)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

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