[HT-03-5] 進行性核上性麻痺と皮質基底核変性症の分子イメージング
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neuropathologically characterized by accumulation of phosphorylated 4-repeat tau in brain. Clinical diagnosis of PSP and CBD is challenging because correlation between clinical phenotypes and underlying neuropathological findings is often inconsistent. Recently, new criteria for PSP diagnosis have been proposed by the Movement Disorder Society-endorsed Study Group. In addition, genetic analysis and molecular imaging study now provide useful information to make accurate diagnosis of PSP and CBD. With disease-modifying therapies being developed, accurate diagnosis of patients in early-stage disease is becoming more urgent. In this symposium, we will discuss how we can make diagnosis of PSP and CBD efficiently on the basis of recent progress of clinical, genetic, neuropathological and neuroimaging analyses.
1980-1986 Kobe University School of Medicine
1986 Resident: Dep. of Radiology, Kobe University Hospital
1987 Junior Physician, Hyogo Prefectural Kobe Children’s Hospital
1988 Senior Physician, Hyogo Prefectural Nishinomimya Hospital
1989 Senior Physician, National Himeji Hospital
1992 Senior Physician, Kobe University Hospital
1992 Chief Investigator, Hyogo Prefectural Government
Guest Researcher, Research Institute for Brain and Blood Vessels Akita
1993 Chief, PET Unit, Div. of Neuroimaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders (HIABCD)
1999 Guest Researcher, Dep. of Nuclear Medicine, Technical University of Munich, Germany
2000 Director, Div. of Neuroimaging Research, HIABCD
2002 Director, Dep. of Radiology, Hyogo Brain and Heart Center,
2009 Associate Professor, Dep. of Radiology, Kindai University Faculty of Medicine
2012 Professor, Dep. of Radiology, Kindai University Faculty of Medicine
Director, Neurocognitive Disorders Center, Kindai University Hospital
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