[HT-05] ホットトピックス05

[HT-05-3] Updates of disease biomarkers of Parkinson's disease

Chin-Hsien Lin (National Taiwan University Hospital)

Present Position
Professor, Department of Neurology, National Taiwan, University Hospital, Taipei, Taiwan.
Director, Clinical Center for Neuroscience and Behavior, National Taiwan, University Hospital, Taipei, Taiwan.

Biosketch
Dr. Lin is now an executive member of Taiwan Movement Disorders Society and is also joining several committees of International Movement Disorders Society, including executive committee of the Asian and Oceanian Section, evidence-based medicine and basic neuroscience committees.

Research Interests:
Genetics and functional studies of familial Parkinson’s disease and movement disorders
Biomarker studies and gut-brain axis of Parkinson’s disease

Selected Publications:
1. Chen SJ, et al. Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Parkinson Disease Patients. Neurology . 2022 doi: 10.1212/WNL.0000000000013225.
2. Lin CH et al. Mild chronic colitis triggers Parkinsonism in LRRK2 mutant mice through activating TNF-α pathway. Movement Disorders 2021, Dec 17. doi: 10.1002/mds.28890.
3. Chang KH, et al., In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation. Stem Cell Research & Therapy 2021 Sep 22;12(1):508. doi: 10.1186/s13287-021-02585-2.
4. Lin CH, et al., Mitochondrial UQCRC1 mutations cause autosomal dominant parkinsonism with polyneuropathy. Brain 2020 Dec 5;143(11):3352-3373.