*Misa Shimuta¹, Daichi Konno^2,3, Takuya Sasaki^2,4, Taro Ishikawa¹ (1. Dept. Pharmacol., Jikei Univ. Sch. of Med., Tokyo, Japan, 2. Lab. Chem. Pharmacol., Grad. Sch. of Pharm. Sci., The Univ. of Tokyo, Tokyo, Japan, 3. Lab. Geriatric Medicine, Grad. Sch. of Med., The Univ. of Tokyo, Tokyo. Japan, 4. Dept. Pharmacol., Grad. Sch. of Pharm. Sci., Tohoku Univ., Sendai. Japan)