*Hsun-Ting Chang¹, Yi-Hong Chen³, Chih-Chieh Yu², Tsai-Te Lu³, Chih-Fei Kao¹, Yun-Ming Wang², Tzai-Wen Chiu^1,2 (1. Department of Biological Science and Technology, National Yang Ming Chiao Tung University, 2. Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, 3. Institute of Biomedical Engineering, National Tsing Hua University)