*Ryohei Tomioka¹, Naoki Shigematsu¹, Toshio Miyashita², Yukie Takahashi¹, Mariko Yamamoto³, Yumiko Yoshimura³, Kenta Kobayashi³, Yuchio Yanagawa⁴, Nobuaki Tamamaki¹, Takaichi Fukuda¹, Wen-Jie Song¹ (1. Faculty of Life Sciences, Kumamoto Univ, Kumamoto, Japan, 2. Teikyo University School of Medicine, Tokyo, Japan, 3. National Institute for Physiological Sciences, Okazaki, Japan, 4. Grad Sch Med, Gunma Univ, Gunma, Japan)