[2P] 69 Alzheimer's Disease and Dementia

[2P-309] Young 5XFAD mice recapitulate preclinical Alzheimer's disease biomarker changes in cerebrospinal fluid and plasma

*Hiroko Yagihara¹, Toshihide Takeuchi², Yuko Saito³, Eiko N. Minakawa¹, kazuhiko seki¹ (1. Department of Neurophysiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan., 2. Life Science Research Institute, Kindai University, Osaka-Sayama, Osaka, Japan, 3. Department of Neuropathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-Ku, Tokyo, Japan)

Keywords:Alzheimer's disease, Fluid biomarker, 5XFAD mice, Amyloid beta