[2Pa] Neurodegenerative Disorders

[2Pa-179] RNA foci formation in neuronal nuclei of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS)

○Taishi Wada¹, Hiroshi Doi¹, Masaki Okubo¹, Mikiko Tada¹, Naohisa Ueda², Hidefumi Suzuki³, Wakana Tominaga¹, Haruki Koike⁴, Haruko Nakamura¹, Keita Takahashi¹, Misako Kunii¹, Yosuke Miyaji¹, Eriko Koshimizu⁵, Satoko Miyatake^5,6, Masahisa Katsuno^4,7, Satoshi Fujii⁸, Hidehisa Takahashi³, Naomichi Matsumoto⁵, Hideyuki Takeuchi¹, Fumiaki Tanaka¹ (1. Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 2. Department of Neurology, Yokohama City University Medical Center, 3. Department of Molecular Biology, Yokohama City University Graduate School of Medicine, 4. Department of Neurology, Nagoya University Graduate School of Medicine, 5. Department of Human Genetics, Yokohama City University Graduate School of Medicine, 6. Clinical Genetics Department, Yokohama City University Hospital, 7. Department of Clinical Research Education, Nagoya University Graduate School of Medicine, 8. Department of Molecular Pathology, Yokohama City University Graduate School of Medicine)

Keywords:non-coding repeat expansion, RNA toxicity, neuropathology, RFC1