BISC Poster Session

[BISCp-20] Quantification of age-dependent acute and cumulative effects of safety-dose doxorubicin hydrochloride on the cardiac dynamics of larval zebrafish

Min Lee¹, Yu-Hsuan Huang¹, Yin-Jhen Jian¹, Huai-Jen Tsai², *Po-Sheng Hu¹ (1. College of Photonics, National Yang Ming Chiao Tung University, 2. School of Medicine and department of life science, Fu Jen Catholic University)

This study investigates the acute and cumulative effects of doxorubicin (DOX) on the age-dependent cardio-dynamic parameters of zebrafish larvae using lightsheet fluorescence microscopy. Experimental results indicate the lethal dosage beyond 15 ppm for the elder group, and better tolerance up to 60% survival rate at 20 ppm for the younger group.