Session 7

[OMC9-02] Detection of a variety of DNA sequences via optical condensation of multiple-sized particles at the solid-liquid interface

*Shuichi Toyouchi^1,2, Seiya Oomachi^1,2,3, Ryoma Hasegawa^1,2,3, Kota Hayashi^1,2,3, Yumiko Takagi^1,2, Mamoru Tamura^1,4, Shiho Tokonami^1,3, Takuya Iida^1,2 (1. Osaka Metropolitan University, RILACS, 2. Osaka Metropolitan University, Department of Physics, Graduate School of Science, 3. Osaka Metropolitan University, Department of Applied Chemistry, Graduate School of Engineering, 4. Osaka University, Department of Material Engineering Science, Graduate School of Engineering Science)

We reveal that light-induced acceleration of DNA hybridization can be accelerated by optical condensation of multiple-sized particles modified with probe DNA and target DNA at solid-liquid interface. By applying this mechanism, we detected a single mutation in DNA with just 5 minutes of light irradiation. The obtained results provide a rapid, sensitive, and cost-effective analysis of a variety of DNA sequences using optical force and photothermal effect.