[S40] Chemical Biology for Pharmaceutical Sciences (Visualization and elucidation of biological phenomena by functional molecules)

Mon. Mar 29, 2021 1:15 PM - 3:15 PM [Room H] Oral Presentation H (Online)

Organizer: Hanaoka Kenjiro (Grad. Sch. of Pharm. Sci., The Univ. of Tokyo), Tsukiji Shinya (Grad. Sch. of Eng., Nagoya Inst. of Tech.)

In the analysis of biological phenomena and the elucidation of pathological mechanisms, smart molecules having special functions enable the visualization and control of biological phenomena, which have not been achieved. Since these molecules exhibit their various abilities in biological samples by precisely designing the molecular structures, this chemical approach has been increasingly needed year by year. In this symposium, cutting edge early and mid-career scientists in the field of chemical biology who are trying to visualize or elucidate biological phenomena by using their own functional molecules will give talks as symposists or participate as organizers in order to introduce their latest research results and to discuss future prospects. Specifically, we will have talks about analytical method of lipid-derived radicals (Dr. Yamada), protein knockdown techniques (Dr. Ishikawa), oligonucleotide-based agonists for controlling receptor activity (Dr. Ueki), fluorescent proximal cell labeling technique (Dr. Kuchimaru), protein activity control by synthetic protein condensates (Dr. Tsukiji), fluorescent probes for visualizing biological phenomena (Dr. Hanaoka), and Prof. Hanaoka and Dr. Tsukiji will promote discussion as organizers.

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趣旨説明：花岡健二郎（東大院薬） (1:15 PM - 1:16 PM)

1:16 PM - 1:38 PM

[S40-1] Decrease of the amount of intracellular target proteins by bioactive molecules

○Minoru Ishikawa¹ (1. Grad. Sch. of Life Sci., Tohoku Univ.)

1:38 PM - 2:00 PM

[S40-2] Structural analysis of lipid-derived radicals and oxidized lipids

○Ken-ichi Yamada^1,2 (1. Facul. of Pharm. Sci., Kyushu Univ., 2. AMED-CREST)

2:00 PM - 2:15 PM

[S40-3] Control of intracellular protein activity using synthetic protein-assembled condensates

○Shinya Tsukiji¹ (1. Grad. Sch. of Eng., Nagoya Inst. of Tech.)

2:15 PM - 2:30 PM

[S40-4] Development of an activatable fluorescent probe utilizing fluorescence quenching based on twisted intramolecular charge transfer (TICT) mechanism

○Kenjiro Hanaoka¹ (1. Grad. Sch. of Pharm. Sci., The Univ. of Tokyo)

2:30 PM - 2:52 PM

[S40-5] Oligonucleotide-based agonists for growth factor receptors

○Ryosuke Ueki¹ (1. Grad. Sch. of Eng., The Univ. of Tokyo)

2:52 PM - 3:14 PM

[S40-6] Highlighting cancer-stromal cell interactions with fluorescent proximal cell labeling in living tissues

○Takahiro Kuchimaru¹ (1. Cent. for Mol. Med., Jichi Med. Univ.)

まとめ：築地真也（名工大院工） (3:14 PM - 3:15 PM)

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