Symposium

[S40] Latest research on pharmacokinetics and safety evaluation for prediction of drug-induced kidney injury

Mon. Mar 27, 2023 9:00 AM - 11:00 AM [Room G2] Conference Hall (1F)

Organizer: Hiroshi Arakawa, Naoki Ishiguro

Drug-induced kidney injury (DIKI) accounts for approximately one-fourth of clinically observed acute kidney injury, and its occurrence can affect dosing regimen and patient prognosis. To evaluate its risk in preclinical research, in vivo analysis using experimental animals is mainly performed. However, DIKI is often firstly observed in clinical trials and practice. The reason for its low predictability is species difference between humans and experimental animals in 1) drug distribution process to the kidney via drug transporters and drug-metabolizing enzymes, and 2) physiological responses of the kidney to DIKI-inducing factors such as drug reaction and hypoxia. Conventionally used renal cells hardly express these pharmacokinetic proteins and have low physiological responsiveness. To overcome the concern, it is important to construct in vitro evaluation system using human-derived cells and biomarkers which can predict clinical observation. In this symposium, we raise issues in the evaluation of pharmacokinetics in the kidney and DIKI in drug discovery and development in pharma industry. Moreover, we introduce novel approaches about cell culture systems for DIKI and biomarkers related to the progression to chronic lesion from DIKI.

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趣旨説明：荒川大（金沢大院医薬保） (9:00 AM - 9:05 AM)

9:05 AM - 9:27 AM

[S40-01] Expectations of in vitro human proximal tubular cell system for DMPK and toxicology in industry

○Naoki Ishiguro¹, Asami Saito¹, Gaku Morinaga¹, Masahito Takatani¹, Ryo Takahashi¹, Takashi Kudo¹, Akiko Matsui¹, Takuma Katayama¹ (1. Nippon Boehringer Ingelheim. Co., Ltd.)

9:27 AM - 9:49 AM

[S40-02] Establishment of 3D-cultured kidney model for application to the evaluation methods of pharmacokinetics and toxicity

○Takahashi Etsushi¹, Kitagawa Fumihiko¹, Kondo Masayuki¹, Jimbo Yoichi¹ (1. NIKKISO CO., LTD.)

9:49 AM - 10:11 AM

[S40-03] Construction of in vitro evaluation system for transporter-mediated drug-induced kidney injury

○Hiroshi Arakawa¹, Daichi Higuchi¹, Ikumi Tamai¹ (1. Faculty of Pharmaceutical Sciences, Kanazawa University)

10:11 AM - 10:32 AM

[S40-04] Elucidation of regulation mechanism of renal OAT1 and OAT3 expressions and an approach to reduce drug-induced kidney injury using 3D-RPTEC

○Itsuki Yokoseki¹, Masataka Nakano^1,2, Tatsuki Fukami^1,2, Miki Nakajima^1,2 (1. Faculty of Pharmaceutical Sciences, Kanazawa University, 2. WPI Nano Life Science Institute, Kanazawa University)

10:32 AM - 10:55 AM

[S40-05] Search for the biomarker capable of predicting reversibility of drug-induced kidney injury

○Kohei Matsushita¹ (1. Div. Pathol., NIHS)

総括：石黒直樹（日本ベーリンガーインゲルハイム（株）） (10:55 AM - 11:00 AM)

Session information