[S45] Toxic AGEs (TAGE) in health

Sat. Mar 30, 2024 3:30 PM - 5:30 PM [Room 302] Conference Center 302 (3F)

Organizer: Masayoshi Takeuchi (Med. Res. Inst., Kanazawa Med. Univ.), Yoshiki Koriyama (Grad. School Pharm. Sci., Suzuka Univ. of Med. Sci.)

Recent studies suggest that advanced glycation end-products (AGEs) are one of the factors involved in the onset and progression of lifestyle-related diseases (LSRD). Thus, suppressing the effects of AGEs may be effective in treating and preventing the onset and progression of LSRD. However, various AGEs are produced by a number of biological pathways in the body. Specifically, AGEs derived from glyceraldehyde, a triose metabolic intermediate of glucose and fructose, have been shown to be associated with the onset and progression of LSRD by damaging various cells. This discovery has led to the concept of toxic AGEs (TAGE). It has also been shown that elevated blood TAGE levels, which are associated with various types of cellular damage, may be a novel biomarker for prevention, early diagnosis, and treatment response of LSRD. By understanding the levels of blood TAGE, it may be possible to predict the onset and progression of the disease at an early stage. This will further contribute to the prevention of LSRD and the extension of a healthy life expectancy.
This symposium will provide an overview of the "novel target TAGE" in human health.

(References: Diabetol. Metab. Syndr. 2020, 12: 105; Biomolecules 2021, 11: 387; Cells 2022, 11: 2178; Antioxidants 2023, 12: 748; J. Kanazawa Med. Univ. 2023, 48: 1 & 12)

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オーガナイザー挨拶、趣旨説明：竹内正義（金沢医大総合医学研） (3:30 PM - 3:32 PM)

3:32 PM - 3:40 PM

[S45-1] Introduction: Overview of toxic AGEs (TAGE)

○Masayoshi Takeuchi¹ (1. Med. Res. Inst., Kanazawa Med. Univ.)

3:40 PM - 4:00 PM

[S45-2] TAGE and liver injury

○Akiko Sakai¹, Kenji Takeda¹, Masayoshi Takeuchi¹ (1. Med. Res. Inst., Kanazawa Med. Univ.)

4:00 PM - 4:20 PM

[S45-3] TAGE-proteins identification in neurons and its dependent axonal degeneration

○Yoshiki Koriyama¹, Ayako Furukawa¹, Hayahide Ooi¹ (1. Grad. School Pharm. Sci., Suzuka Univ. of Med. Sci.)

4:20 PM - 4:40 PM

[S45-4] Effect of RASGRP2 on TAGE-induced vascular endothelial dysfunction

○Jun-ichi Takino¹, Shouhei Miyazaki¹, Kentaro Nagamine², Takamitsu Hori¹ (1. Fac. Pharm. Sci., Hiroshima Inter. Univ., 2. Fac. Health Sci., Hiroshima Inter. Univ.)

4:40 PM - 5:00 PM

[S45-5] TAGE induces small intestinal cell injury

○Tamihide Matsunaga^1,2, Eisei Hori^1,2, Misaki Natori², Ryoma Takeda² (1. Grad. Sch. Pharm. Sci., Nagoya City Univ., 2. Fac. Pharm. Sci., Nagoya City Univ.)

5:00 PM - 5:20 PM

[S45-6] TAGE as a marker for lifestyle-related diseases

○Masayoshi Takeuchi¹ (1. Med. Res. Inst., Kanazawa Med. Univ.)

総括：郡山恵樹（鈴鹿医療大院薬） (5:20 PM - 5:30 PM)