[1P-54*] 酵素ロドプシンから発見された新規波長制御残基
Rhodopsin research world has largely progressed due to the discovery of numerous numbers of rhodopsin genes with new functions over the last decade. In addition, the discovery of channelrhodopsin led to the birth of "optogenetics," which enables manipulation of neural activity by light. In optogenetics, long-wavelength lights are desired because they can penetrate into deep animal tissues. Therefore, color control mechanism in rhodopsins attracts broad attention.
In 2019, eight rhodopsin phosphodiesterase (Rh-PDE) genes were reported1. We successfully expressed six Rh-PDEs and measured absorption wavelength spectra2. They were categorized into three groups in terms of absorption maxima. Two of them match with known color turning mechanisms. However, the third one could not be explained by the known mechanism.
In this presentation, we would like to discuss the newly discovered color turning mechanism.
1) Brunet et. al. Science (2019)
2) Sugiura et. al. ACS Omega (2020)
In 2019, eight rhodopsin phosphodiesterase (Rh-PDE) genes were reported1. We successfully expressed six Rh-PDEs and measured absorption wavelength spectra2. They were categorized into three groups in terms of absorption maxima. Two of them match with known color turning mechanisms. However, the third one could not be explained by the known mechanism.
In this presentation, we would like to discuss the newly discovered color turning mechanism.
1) Brunet et. al. Science (2019)
2) Sugiura et. al. ACS Omega (2020)