[2P-1] ポスター2（2P-01ー2P-37）

[2P-30] 分子動力学シミュレーションによるSARS-CoV及びSARS-CoV-2のRNA依存性RNAポリメラーゼにおけるドメイン運動に関する研究

^○伊藤 暁^1,2,3, 谷本 勝一¹, 奥村 久士^1,2,3 (1.分子研, 2.ExCELLS, 3.総研大)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). One of the promising drug targets is an RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. The tertiary structure of the SARS-CoV-2 RdRp is the same as that of the SARS-CoV RdRp. However, the activity of the SARS-CoV RdRp is higher than that of the SARS-CoV-2 RdRp. Such difference is expected to come from a difference in their dynamic properties. We performed molecular dynamics (MD) simulation to investigate the difference in the dynamic properties. We found differences in domain motions between the SARS-CoV and SARS-CoV-2 RdRp.