1:30 PM - 2:45 PM

[1P-033] HIF-1α-PDK1 mediated glycolytic reprogramming plays an essential role in macrophage migratory capacity

^○Hiroaki Semba^1,2, Norihiko Takeda^1,3, Takayuki Isagawa⁴, Yuki Sugiura⁵, Kurara Honda⁵, Masaki Wake¹, Hidenobu Miyazawa⁶, Yoshifumi Yamaguchi⁶, Masayuki Miura⁶, Hajime Abe¹, Katsura Soma¹, Katsuhiro Koyama¹, Manami Kato¹, Ichiro Manabe⁷, Ryozo Nagai⁸, Takeshi Yamashita², Issei Komuro¹ (1.Dep. of Cardiovasc. Med., Graduate school of Medicine, The Univ. of Tokyo, 2.The Cardiovascular Insutitute, 3.PRESTO, JST, 4.Dep. of Cardiovasc. Med., Graduate school of Medicine, Nagasaki Univ., 5.Dep. of Biochem., Graduate school of Medicine, Keio univ., 6.Dep. of Genetics, Graduate school of Pharma., The Univ. of Tokyo, 7.Dep. of Aging Research, Graduate school of Medicine, Chiba Univ., 8.Jichi Medical University)

低酸素, マクロファージ, 遊走, HIF-1α, PDK1