[P-266(2T15m-12)] Development of a selective degrader targeting hematopoietic prostaglandin D synthase

^○Norihito Shibata¹, Hidetomo Yokoo², Akinori Endo³, Takahito Ito^4,5, Yuta Yanase^4,5, Yuki Murakami^4,5, Kiyonaga Fujii⁶, Kazunari Kondo¹, Yasushi Saeki³, Mikihiko Naito⁷, Kosuke Aritake⁸, Yosuke Demizu^4,5 (1.Division of Biochemistry, NIHS, 2.Medical Chemistry, Kyoto Prefectural University of Medicine, 3.Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 4.Division of Organic Chemistry, NIHS, 5.Graduate School of Medical Life Science, Yokohama City University, 6.Laboratory of Analytical Chemistry, Daiichi University of Pharmacy, 7.Laboratory of Targeted Protein Degradation, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 8.Laboratory of Chemical Pharmacology, Daiichi University of Pharmacy)

キーテクノロジー：プロテインノックダウン法

プロスタグランジンD合成酵素、筋ジストロフィー、プロテインノックダウン法