[1P-394（2T16a-04）] Different mitochondrial DNA heteroplasmy distributions at the single-cell level in patients with mitochondrial diseases

Atsuko Okazaki¹, Kazuhiro R. Nitta^1,2, Yukiko Yatsuka¹, ^〇Ayumu Sugiura¹, Masato Arao³, Masaru Shimura⁴, Tomohiro Ebihara⁴, Takanori Onuki⁴, Keiko Ichimoto⁴, Akira Ohtake^3,5,6, Kei Murayama⁴, Yasushi Okazaki^1,2 (1. Diagnostics and Therapeutics of Intractable Diseases, Juntendo University, Graduate School of Medicine, 2.Laboratory for Comprehensive Genomic Analysis, Center for Integrative Medical Sciences, RIKEN, 3.Department of Pediatrics, Saitama Medical University, 4.Department of Metabolism, Chiba Children's Hospital, 5.Center for Intractable Diseases, Saitama Medical University Hospital, 6.Department of Clinical Genomics, Saitama Medical University)

キーテクノロジー：mtDNA single-cell ATAC seq

Mitochondrial disease、Mitochondrial DNA、heteroplasmy、single cell analysis、ATAC-seq