The Japanese Biochemical Society

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[1T06a-08(1P-145)] Development of oligonucleotide-based PROTACs for expanding the applicability of targeted protein degradation

Miyako Naganuma1,2, Nobumichi Ohoka2, Genichiro Tsuji2, Mikihiko Naito3, Takao Inoue2, Yosuke Demiz1,2,4 (1.Graduate School of Medical Life Science, Yokohama City University, 2.National Institute of Health Sciences, 3.Graduate School of Pharmaceutical Sciences, The University of Tokyo, 4.Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University)

キーテクノロジー:ケミカルプロテインノックダウン

PROTAC、ユビキチン-プロテアソーム系、転写因子、デコイ核酸、アプタマー

w215506e@yokohama-cu.ac.jp

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