[4P-0496] Humoral early-aquired IgM avidity depend on IL-13 derived of lymphatic organ protects host from severe systemic infection with S. pneumoniae

〇Natsuo Yamamoto^1,7, Tsuyoshi Suzuki², Kazufumi Ikuta³, Monika Majewska Szczepanik^6,7, Takeshi Machida⁴, Marian Szczepanik^6,7, Hiedehru Sekine⁴, Keiji Kanemitsu¹, Ken Iseki², Hiroko Shimokawa⁵, Philip William Askenase⁷ (1.Dept. of Infect. Cont., Fukushima Med. Univ., 2.Dept. of Emerg. Med., Fukushima Med. Univ., 3.Dep. of Vir., Tohoku Med. Pharm. Univ., 4.Dept. of Immun., Fukushima Med. Univ., 5.Health and Wef. Cent. of Sendai City, 6.Dep. of Health. Sci., Jagiellonian Univ., 7.Sec. of Allerg. and Clin. Immun., Yale Univ.)

IL-13, IgM, sepsis, Streptococcus pneumoniae, NLRP3