Disruption of Actin Dynamics Regulated by Rho Effector mDia1 Attenuates Pressure Overload-Induced Cardiac Hypertrophic Responses and Exacerbates Dysfunction

Ichitaro Abe, ○Takeshi Terabayashi, Katsuhiro Hanada, Takahiro Akamine, Naohiko Takahashi, Toshimasa Ishizaki

[1P-0361] Disruption of Actin Dynamics Regulated by Rho Effector mDia1 Attenuates Pressure Overload-Induced Cardiac Hypertrophic Responses and Exacerbates Dysfunction

Ichitaro Abe¹, ○Takeshi Terabayashi², Katsuhiro Hanada³, Takahiro Akamine², Naohiko Takahashi¹, Toshimasa Ishizaki² (1.Dept. of Cardio. Clini. Exam., Faculty of Medicine, Oita Univ., 2.Dept. of Pharma., Faculty of Medicine, Oita Univ., 3.CERC, Faculty of Medicine, Oita Univ.)

Actin dynamics, Mechanical stress, mDia, Cardiac hypertrophy, Heart failure

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The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1P-0361] Disruption of Actin Dynamics Regulated by Rho Effector mDia1 Attenuates Pressure Overload-Induced Cardiac Hypertrophic Responses and Exacerbates Dysfunction

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