[2P-0082] RNA chemical modifications‚ which decrease thermodynamic stabilities‚ are useful tools to reduce off-target effects caused by siRNAs

〇Seongjin An¹、Yoshiaki Kobayashi²、Kohei Nomura³、Hisroshi Abe³、Kumiko Ui-Tei^1,2 (1.Graduate School of Frontier Sciences, The University of Tokyo、2.Graduate School of Science, The University of Tokyo、3.Graduate School of Science, Nagoya University)

Inosine、Off-target effect、siRNA、RNA modification、Post-transcriptional regulation