Deficiency of MTH1 and/or OGG1 accumulates 8-oxoguanine in brain of <I>App</I><SUP>NL-G-F</SUP> knock-in mouse model of Alzheimer&#700;s disease, accompanied by acceralated microgliosis and anti-anxiety behavior

○Yuri Mizuno, Takashi  Saito, Takaomi  C  Saido, Yusaku  Nakabeppu

[3P-0261] Deficiency of MTH1 and/or OGG1 accumulates 8-oxoguanine in brain of App^NL-G-F knock-in mouse model of Alzheimerʼs disease, accompanied by acceralated microgliosis and anti-anxiety behavior

○Yuri Mizuno¹, Takashi Saito^2,3, Takaomi C Saido³, Yusaku Nakabeppu¹ (1.Div. Neurofunctional Genomics, Med. Inst. Bioreg., Kyushu Univ., 2.Dept. Neurocognitive Sci., Grad. Sch. Med. Sci., Nagoya City Univ., 3.Lab. Proteolytic Neuroscience, RIKEN Center for Brain Sci.)

Alzheimerʼs disease, App^{NL-G-F/NL-G-F} mouse, 8-oxoguanine, microglia, anti-anxiety behavior

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The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0261] Deficiency of MTH1 and/or OGG1 accumulates 8-oxoguanine in brain of App^NL-G-F knock-in mouse model of Alzheimerʼs disease, accompanied by acceralated microgliosis and anti-anxiety behavior

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The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0261] Deficiency of MTH1 and/or OGG1 accumulates 8-oxoguanine in brain of AppNL-G-F knock-in mouse model of Alzheimerʼs disease, accompanied by acceralated microgliosis and anti-anxiety behavior

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[3P-0261] Deficiency of MTH1 and/or OGG1 accumulates 8-oxoguanine in brain of App^NL-G-F knock-in mouse model of Alzheimerʼs disease, accompanied by acceralated microgliosis and anti-anxiety behavior