[3P-0408] An immortalized cell-based spheroidal human blood-brain barrier model for molecular analysis of its normal and diseased conditions

○Satomi Nambu¹, Keita Kitamura^1,2, Kenta Umehara², Ryo Ito³, Yoshiyuki Yamaura⁴, Takafumi Komori⁵, Hidetaka Akita², Tomomi Furihata¹ (1.Laboratory of Clinical Pharmacy & Experimental Therapeutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan, 2.Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan., 3.Research Center of Neurology, Ono Pharmaceutical Co., Ltd., Osaka, Japan., 4.Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka, Japan., 5.Drug Metabolism and Pharmacokinetics Tsukuba, Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.)

The blood-brain barrier (BBB) , brain diseases, BBB inflammation , a human immortalized cell-based multicellular spheroid BBB