第57回日本小児循環器学会総会・学術集会

講演情報

JCK Session

Session 02(II-JCK02)
Kawasaki Disease/General Cardiology

2021年7月10日(土) 10:40 〜 12:10 Track5 (Web開催会場)

Chair:Hiroyuki Yamagishi(Department of Pediatrics, Keio University School of Medicine, Japan)
Chair:Fang Liu(Cardiac Center, Children’s Hospital of Fudan University, China)
Jong-Woon Choi(Department of Pediatrics, Bundang Jesaeng Hospital, Daejin Medical Center, Korea)

[II-JCK02-4] COVID-19 and Kawasaki disease : A survey in Chinese pediatric population

Guoying Huang1, Fang Liu1, Liping Xie1, Yin Wang2, Weili Yan2, On Behalf of The Study Team of China Kawasaki Disease Research Collaborative Group (1.Heart Center, Children’s Hospital of Fudan University, National Children’s Medical Center, China, 2.Department of Epidemiology, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China)

Background: Increasing cases of children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presenting with severe Kawasaki-like disease have been reported in some Western countries, raising the possibility of SARS-CoV-2 being a trigger of Kawasaki disease (KD). We aimed to investigate whether KD is linked to coronavirus disease 2019 (COVID-19) in Chinese pediatric population.
Methods: Patients were enrolled if diagnosed with KD in the 40 hospitals of China Kawasaki Disease Research Collaborative Group from January to April 2020, the COVID-19 epidemic period in China. Information of demographic data, KD shock syndrome, macrophage activation syndrome, evidence of SARS-CoV-2 infection and the number of KD cases were retrospectively analyzed.
Results: The completed response was received from 29/40 hospitals (72.5%) across 19 provinces. Of 2108 KD patients enrolled, the median age was 1.9 years and 63.8% were male. KD shock syndrome and macrophage activation syndrome were diagnosed in eight (0.4%) and two (0.1%) patients, respectively, none of whom had contact history with COVID-19 patients. Greater number of KD cases from January to April 2020 than the upper limit of 95% CI of estimated numbers of cases of the past three years were observed in only two out of 29 (6.9%) hospitals. RT-PCR tests in 434 patients and antibody tests in 64 patients for SARS-CoV-2 were all negative, including nine with exposure history.
Conclusions: There is no evidence of the link of KD with COVID-19 in Chinese children in terms of its prevalence and severity.