*Kazuya Nagasaki¹, Masashi Izumiya², Ohtake Yoichi³, Noriko Kawashima⁴, Akira Kuriyama⁵, Michito Sadohara⁶, Kiyoshi Shikino^7,8, Yoshito Nishimura⁹, Saori Nonaka¹⁰, Takahiro Matsuo¹¹, Mitsuru Moriya¹², Noriko Yamamoto¹³, Tetsuya Makiishi¹⁴ (1. Department of Internal Medicine, Mito Kyodo General Hospital, 2. Research Center for Medical Education, Tokyo University, 3. Department of Internal Medicine, Itami Seifu Hospital, 4. Kawashima Neurology Clinic, 5. Emergency and Critical Care Center, Kurashiki Central Hospital, 6. Department of Community, Family, and General Medicine, Kumamoto University Hospital, 7. Department of Community-based Medical Education, Graduate School of Medicine Chiba University, 8. Department of General Medicine, Chiba University Hospital, 9. Department of Medicine, John A. Burns School of Medicine, University of Hawai'i, 10. Department of Internal Medicine, Taito Hospital, 11. Department of Infectious Diseases, St. Luke's International Hospital, 12. Department of Psychosomatic Internal Medicine, Health Sciences University of Hokkaido Hospital, 13. Yamamoto Clinic, 14. Department of General Medicine, Faculty of Medicine, Shimane University)