[D10-12] 医療用加速器，NCT

[D12] In vivo evaluation of Gd-DTPA incorporated into calcium phosphate nanoparticle as neutron capture therapy agent

^〇Dewi Novriana¹, Yanagie Hironobu^1,2, Atsuko Shinohara³, Kazuhito Yokoyama⁴, Yuriko Sakurai², Takeshi Nagasaki⁵, Jun Nakajima^2,6, Minoru Ono^2,7, Cabral Horacio⁸, Mi Peng ⁸, Kataoka Kazunori^8,9, Hiroyuki Takahashi^1,2 (1.Department of Nuclear Engineering & Management, The University of Tokyo, 2.Cooperative Unit of Medicine & Engineering, The University of Tokyo, 3.Research Institute for Cultural Sciences, Seisen University, 4.Department of Epidemiology and Environmental Health, Juntendo University, 5.Department of Applied Chemistry and Bioengineering, Osaka City University, 6.Department of Respiratory Surgery, University of Tokyo Hospital, 7.Department of Cardiac Surgery, University of Tokyo Hospital, 8.Department of Bioengineering, The University of Tokyo, 9.Department of Materials Engineering, The University of Tokyo)

Keywords:gadolinium, neutron capture therapy, calcium phosphate, nanoparticle

To evaluate therapeutic gain of Gd-based neutron capture therapy (NCT), we investigate the feasibility of utilizing Gd-DTPA incorporated into calcium phosphate nanoparticle as NCT agent by performing in vivo experiment on colon-26 tumour-bearing mice, irradiated at Kyoto University Research Reactor. Experimental data as well as pathological analysis will be presented as preliminary results.