[2J05-08] Radiation Medicine and Biological Influence 2

[2J06] Study on the suppression effect of mouse renal injury by the Radon inhalation

*Kaori Sasaoka^1,4, Takahiro Kataoka¹, Norie Kanzaki^1,2, Yusuke Kobashi¹, Akihiro Sakoda², Yuu Ishimori³, Kiyonori Yamaoka¹ (1. Okayama University,Graduate school of Health Sciences, 2. Japan Atomic Energy Agency, Ningyou-toge Environmental Engineering Center, 3. Japan Atomic Energy Agency, Prototype Fast Breeder Reactor Monju, 4. Okayama University, Graduate school of Medicine, Dentistry and Pharmaceutical Sciences )

Keywords:Radon inhalation, Mouse, Renal injury, Cisplatin

Mouse renal injury caused by the oxidative stress of cisplatin after radon inhalation was verified. When the high radiosensitive mouse was treated with the lowered dose of cisplatin after radon inhalation, the antioxidant content was increased and creatinine level was decreased. The supportive effect of Radon inhalation would be a good potential as the candidate treatment to alleviate the cisplatin induced renal injury in the veterinary field.