Oral 4: Growth

Sat. Nov 19, 2016 10:45 AM - 11:45 AM Room 1 (Hall C)

Moderator: Junko Ito (The Head of Department of Pediatrics, Toranomon Hospital Tokyo), Melinda Atienza (Department of Pediatrics Faculty of Medicine and Surgery University of Santo Tomas Manila)

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10:45 AM - 10:55 AM

[O4-1] A reversible albumin-binding once-weekly growth hormone (GH) treatment (somapacitan; NNC0195-0092) induces a dose-dependent IGF-I response similar to daily GH therapy in children with growth hormone deficiency (GHD)

Tadej Battelino¹, ^○Michael Højby Rasmussen², Jean de Schepper³, Nehama Zuckerman-Levin⁴, Zoran Gucev⁵, Lars Sävendahl⁶ (1.Faculty of Medicine, University of Ljubljana, 2.Global Development, Novo Nordisk A/S, 3.Division of Paediatric Endocrinology, Universitair Ziekenhuis Brussel, 4.Pediatric and Obesity Clinic, Rambam Medical Center, 5.University Paediatrics Clinic, Medical Faculty Skopje, 6.Department of Women’s and Children’s Health, Karolinska Universitetssjukhuset)

10:55 AM - 11:05 AM

[O4-2] Machine Learning and Transcriptomics Accurately Predict Diagnosis and Severity of Childhood Growth Hormone Deficiency

^○Philip Murray¹, Adam Stevens¹, Ekaterina Koledova², Pierre Chatelain³, Peter Clayton¹ (1.University of Manchester and Royal Manchester Children’s Hospital, 2.Merck KGaA, 3.Universit? Claude Bernard)

11:05 AM - 11:15 AM

[O4-3] Comprehensive clinical studies in 30 patients molecularly diagnosed with Temple syndrome

^○Masayo Kagami¹, Keisuke Nagasaki², Rika Kosaki³, Horikawa Reiko⁴, Yasuhiro Naiki⁴, Shinji Saitoh⁵, Toshihiro Tajima⁶, Akie Nakamura¹, Keiko Matsubara¹, Maki Fukami¹, Tsutomu Ogata^1,7 (1.Department of Molecular Endocrinology, National Research Institute for Child Health and Development, 2.Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, 3.Department of Clinical Laboratory Medicine, National Center for Child Health and Development, 4.Division of Endocrinology and Metabolism, National Center for Child Health and Development, 5.Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 6.Department of Pediatrics, Jichi Children's Medical Center Tochigi, 7.Department of Pediatrics, Hamamatsu University School of Medicine)

11:15 AM - 11:25 AM

[O4-4] Genome-wide copy-number analysis of fifty Silver-Russell syndrome patients without known etiology

^○Takanobu Inoue^1,2, Akie Nakamura¹, Tomoko Fuke¹, Kazuki Yamazawa¹, Shinichiro Sano¹, Keiko Matsubara¹, Akira Oka², Maki Fukami¹, Masayo Kagami¹ (1.Department of molecular endocrinology, National Center for Child Health and Development, 2.Department of Pediatrics, The University of Tokyo Hospital)

11:25 AM - 11:35 AM

[O4-5] Efficacy and safety of recombinant human growth hormone treatment in patients with short stature related to bone and cartilage diseases

^○Guangling Li¹, Shiyao Wang¹, Huijuan Zhu¹, San A², Hongbo Yang¹, Linjie Wang¹, Fengying Gong¹, Zimeng Jin¹, Hui Pan¹ (1.Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science, 2.Tianjin Enterprise Key Laboratory of Clinical Molecular Diagnostic, Binhai Genomics Institute,BGI-Tianjin)

11:35 AM - 11:45 AM

[O4-6] A hybrid Fc-fused human growth hormone, GX-H9, shows a potential for semi-monthly administration in both adult and pediatric growth hormone deficiencies.

^○H. Michael Keyoung¹, Aryaev Mykola², Eun Jig Lee³, Jochen Schopohl⁴, Tae Kyung Kim¹, Young-Joo Ahn⁵, Jung-Won Woo¹, Woo Ick Jang⁵, Young-Chul Sung¹ (1.Genexine, Inc., 2.Department of pathology of the newborns and premature infants, Municipal Institution, 3.Department of Internal Medicine IV, Ludwig-Maximilians University Munich, 4.Endocrinology/ Internal Medicine, Yonsei University College of Medicine, 5.Handok, Inc.)