[P-66] A Mechanism for Maintaining Zinc Homeostasis through Reduction in H3K14ac under Zinc Deficiency

*Satoshi Takenaka¹, Takao Fujisawa¹, Hidenori Ichijo¹ (1. The University of Tokyo)

[P-67] A Study of Iron Uptake Ability and Respiratory Pathway of a Laboratory-Evolved Catalase Deficient Escherichia coli Strain

*Kanako Tada¹, Norifumi Kawakami¹, Yuki Horiuchi¹, Hiromu Yamaguchi¹, Risa Matsuki¹, Kenji Miyamoto¹ (1. Faculty of Sci. and Tech., Keio University)

[P-68] Manganese Disturbs the Cellular Zinc Homeostasis

*Yukina Nishito¹, Yoshiki Kamimura¹, Nao Yamamoto¹, Hitomi Fujishiro², Hiroyuki Yaui³, Taiho Kambe¹ (1. Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan, 2. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan, 3. Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences, Kyoto Pharmaceutical University, Kyoto, Japan)

[P-69] Structural Analysis of a Heme-Containing Oxygen Sensor Protein, HemAT

*Rei Tohda¹, Norifumi Muraki², Takeshi Yokoyama³, Shigetoshi Aono¹ (1. Exploratory Research Center on Life and Living Systems, 2. Keio University, 3. Tohoku University)

[P-70] Laboratory Domestication of Methylosinus trichosporium OB3b under Glycerol Stress and Characterization of Gene Involved in Lanthanide Uptake

*Wataru Shiina¹, Hidehiro Ito¹, Toshiaki Kamachi¹ (1. Tokyo Institute of Technology)

[P-71] Regulation of Iron Homeostasis by VgrR-VgrS, a Two-Component System from X. campestris

*Dayeon Nam^1,2, Tomohide Saio³, Norifumi Muraki^1,2, Rei Tohda^1,2, Shigetoshi Aono^1,2 (1. Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 2. Institute for Molecular Science, National Institutes of Natural Sciences, 3. Institute of Advanced Medical Sciences, Tokushima University)

[P-72] Analysis of Genomic Mutation Trends in Escherichia coli Populations Cultured in the Presence of Ruthenium for Long-Term

*Daichi Kasugahara¹, Norifumi Kawakami¹, Yuki Horiuchi¹, Hiromu Yamaguchi¹, Kenji Miyamoto¹ (1. Faculty of Sci. and Tech., Keio University)

[P-73] Bismuth Drugs Target Iron Homeostasis to Sensitizes Pseudomonas aeruginosa to Multiple Antibiotics

*Yushan Xia^1,2,3, Rubén Cebrián¹, Peng Gao², Anne de Jong¹, Weihui Wu³, Richard Yi-Tsun Kao², Hongyan Li², Hongzhe Sun², Oscar P. Kuipers¹ (1. University of Groningen, 2. The university of HongKong, 3. Nankai University)

[P-74] Metallo-Sideromycin: A Double Trojan Horse Strategy for Combating Antimicrobial Resistance

*Chenyuan Wang¹, Yushan Xia¹, Runming Wang¹, Jingru Li¹, Chun Lung Chan¹, Patrick Henry Toy¹, Hongyan Li^1,2, Hongzhe Sun^1,2 (1. Department of Chemistry, The University of Hong Kong, 2. State Key Laboraotry of Synthetic Chemistry and CAS-HKU Joint Laboratory of Metallomics for Health and Environment, The University of Hong Kong)

[P-75] Potentiating Antimicrobial Activity of Bismuth(III) to Overcome Multidrug-Resistant Bacteria Using Hinokitiol and Its Derivatives

*Ka Yan Tiffany Ip¹, Runming Wang¹, Derek Chun-Lung Chan¹, Hongyan Li¹, Hongzhe Sun¹ (1. The University of Hong Kong)

[P-76] Nsp14/nsp10 Complex Serves as an Important Target for Antivirals against SARS-CoV-2: Discovery of Metallo-Antiviral Agents

*Jingxin Chen¹, Shuofeng YUAN², Jasper FW CHAN², Hongyan LI¹, Hongzhe SUN¹ (1. Department of Chemistry, The University of Hong Kong, 2. Department of Microbiology, The University of Hong Kong)

[P-77] Mechanistic Insight into Nitric Oxide Delivery of Photo-Cleavable Cobalt(III)–Nitrosyl Complex at Single-Cell Level

*Jisu Choe¹, Jaeheung Cho¹ (1. Ulsan National Institute of Science and Technology (UNIST))

[P-78] Dual Targeting Drug Delivery Strategy for Precise Medicine: Simultaneous Nasal and Lung Delivery of Metallodrug against SARS-CoV-2

*Suyu Wang¹, Han Cong Seow¹, Runming Wang¹, Hongyan Li¹, Ka Wing Jenny Lam¹, Hongzhe Sun¹ (1. The University of Hong Kong)

[P-79] In vivo Anticancer Efficacy and X-ray Crystal Structure of the Tetrazolato-Bridged Dinuclear Pt(II) Complex

*Takuma Yamada¹, Keiichi Hiramoto¹, Masako Uemura¹, Seiji Komeda¹ (1. Suzuka Univ. Med. Sci.)

[P-80] Gold-based Agents as Effective Broad-spectrum Inhibitors to B1, B2 and B3 Subclasses of Metallo-β-lactamase

*Yuen Ting Wong¹, Runming Wang¹, Ho Ching Ho¹, Pak Leung Ho², Richard YT Kao², Hongyan Li¹, Hongzhe Sun¹ (1. Department of Chemistry, The University of Hong Kong, 2. Department of Microbiology, The University of Hong Kong)

[P-81] Bismuth(III) and Gold(I) Complexes as Antimicrobial Agents for Resistant Bacteria

*Chun Lung Chan¹, YuShan Xia¹, XueYing Wei¹, JinXin Chen¹, HongYan Li¹, Hongzhe Sun¹ (1. Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P.R. China)

[P-82] Organometallic Complexes of Indoleamine 2,3-dioxygenase 1 Inhibitors

*Anna Wieczorek-Blauz^1,2, Julia Stjärnhage², Andrzej Blauz³, Christian Hartinger² (1. Department of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland, 2. Schoolof Chemical Sciences, University of Auckland Private Bag 92019, Auckland 1142, New Zealand, 3. Cytometry Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska St., 90-236 Lodz, Poland)

[P-83] Interaction of Phenolbenzimidazole Complexes with DNA

*Nurul Huda Abd Karim¹, Nor Falahiah Ismail¹ (1. Department of Chemical Sciences, Faculty of Science & Technology, University Kebangsaan Malaysia, 43650 Bangi, Selangor)

[P-84] A Novel Bismuth Contrast Agent for Computed Tomography of Cartilage

Abhisek Bhattarai¹, *Jamie Guan-tai Lok¹, Hongzhe Sun¹, Varut Vardhanabhuti¹ (1. The University of Hong Kong)

[P-85] Bismuth(III) Compounds Eradicate Burkholderia cepacia via Targeting Multiple Pathways and Restore Susceptibility of Persister Cells to Antibiotics

*Jingru Li¹, haibo wang¹, runming wang¹, yushan xia¹, peng gao¹, Yi-Tsun Kao¹, Hongyan Li¹, Hongzhe Sun¹ (1. the university of Hong Kong)

[P-86] Hydrogen Generation by Reaction of Si-based Agent with Water in the Presence of Metal Atoms and Its Medical Application

*Pinyu Chen¹, Yuki Kobayashi¹, Hikaru Kobayashi¹, Shoichi Shimada¹, Yasuhiro Funahashi¹ (1. OSAKA Univ.)

[P-87] Excited-State Intramolecular Hydrogen Transfer of Compact Molecules Controls Amyloid Aggregation Profiles

*Mingeun Kim¹, Mannkyu Hong^1,2, Jiwon Yoon³, Seung-Hee Lee³, Mu-Hyun Baik^1,2, Mi Hee Lim¹ (1. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea, 2. Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon 34141, Republic of Korea, 3. Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea)

[P-88] A Nonheme Ferrous Apoptosis-Ferroptosis Hybrid Strategy Efficiently Kills Renal Cancer Cells via Fenton Reaction

*Hyungbin Park¹, Hyeri Jeon¹, Chaewon Ahn¹, Seungwoo Hong¹ (1. Department of Chemistry, Sookmyung Women’s University, Korea)

[P-89] Quantum Effects on Stable Isotope Ratios of Metals in Human Body for Prognostic Evaluation

*Kei Sawada¹ (1. RIKEN SPring-8 Center)

[P-90] Quantitative Mapping of Subcellular Labile Zn²⁺ Concentrations Using Localizable Small-Molecule Fluorescent Probes

*Rong Liu¹, Toshiyuki Kowada¹, Toshitaka Matsui¹, Shin Mizukami¹ (1. Tohoku University)

[P-91] Design and Synthesis of Ni-NTA-based Fluorescent Probe for Mining Intracellular Metalloproteomes

*Hongyu Zhao¹, Chunlung Chan¹, Hongyan Li¹, Hongzhe Sun¹ (1. The University of Hong Kong)

[P-92] Discriminant of Metal Sensing Using Carbon Dots Sensing Array

*Haobo Guo¹ (1. The University of Sydney)

[P-93] Core and Rod Structures of a Thermophilic Cyanobacterial Light-Harvesting Phycobilisome

*Keisuke Kawakami¹, Tasuku Hamaguchi², Yuu Hirose³, Daisuke Kosumi⁴, Makoto Miyata⁵, Nobuo Kamiya⁵, Koji Yonekura¹ (1. RIKEN SPring-8 Center, 2. Tohoku Univ, 3. Toyohashi Univof Tech, 4. Kumamoto Univ, 5. Osaka Metropolitan Univ)

[P-94] Syntheses and Properties of Iron Porphyrin Complexes with Proton/Electron Transfer Moieties

*Maho Imai¹, Kento Kosugi¹, Yutaka Saga¹, Mio Kondo^1,2, Shigeyuki Masaoka¹ (1. Osaka Univ., 2. JST PRESTO)

[P-95] Development of a Function-Integrated System for Water Oxidation by Electrochemical Polymerization of Pentanuclear Iron Complexes

*Takumi Matsuzaki¹, Hikaru Iwami¹, Yutaka Saga¹, Mio Kondo^1,2, Shigeyuki Masaoka¹ (1. Osaka Univ., 2. JST PRESTO)

[P-96] Primary Coordination Sphere Controlled Mechanistic Chemistry of the Mn₄CaO_x Cluster in Photosystem II

*Hiroshi Isobe¹ (1. Research Institute for Interdisciplinary Science, Okayama University)

[P-97] Converting Cytochrome c into a DyP-like Enzyme

*Issei Omura¹, Koichiro Ishimori^1,2, Takeshi Uchida^1,2 (1. Graduate School of Chemical Sciences and Engineering, Hokkaido University, 2. Department of Chemistry, Faculty of Science, Hokkaido University)

[P-98] Conversion of a Monomeric Protein into a Domain-swapped Dimer by Utilizing a Tight Hydrogen Bond Network at the Hinge Region for Myoglobin

*Cheng Xie¹, Hiromitsu Shimoyama², Masaru Yamanaka¹, Satoshi Nagao¹, Hirofumi Komori³, Naoki Shibata⁴, Yoshiki Higuchi⁴, Yasuteru Shigeta², Shun Hirota¹ (1. Nara Institute of Science and Technology, 2. Univ. of Tsukuba, 3. Kagawa Univ., 4. Univ. of Hyogo)

[P-99] Hydroxylation of Propane Catalyzed by Intracellular Cytochrome P450BM3 Activated by Amino Acid Derivatives

*Yuki Sugai¹, Masayuki Karasawa¹, Yusaku Kodama¹, Shinya Ariyasu¹, Yuichiro Aiba¹, Osami Shoji¹ (1. Graduate School of Science, Nagoya University)

[P-100] Directed Evolution of Myoglobin Reconstituted with an Iron Corrole Complex Using a Screening Platform Based on an Affinity Purification System

*Koki Takeuchi¹, Shunsuke Kato¹, Takashi Hayashi¹ (1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Japan)

[P-101] Artificial Metalloenzymes with 2-His-1-carboxylate Facial Triads toward Stereoselective Michael Addition Reaction

*Ryusei Matsumoto¹, Saho Yoshioka¹, Yoshitsugu Morita¹, Nobutaka Fujieda¹ (1. Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University)

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