Kinetic and Crystallographic Studies Reveal That Traboulsi Syndrome-Associated Active Site Variants of the Metalloprotein Aspartate/asparagine-β-hydroxylase Suffer from Impaired Fe(II) Binding and are Less Catalytically Active

3:10 PM - 3:25 PM

[O-04] Kinetic and Crystallographic Studies Reveal That Traboulsi Syndrome-Associated Active Site Variants of the Metalloprotein Aspartate/asparagine-β-hydroxylase Suffer from Impaired Fe(II) Binding and are Less Catalytically Active

*Lennart Brewitz¹, Amelia Brasnett¹, Cynthia Hou¹, Patrick Rabe¹, Christopher J. Schofield¹ (1. University of Oxford)

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