Fri. Oct 11, 2019 4:30 PM - 6:10 PM Room 13 (501)

Organizer / Chair: ‌Ryota HASHIMOTO (Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan), Co-chair: ‌Michio SUZUKI (Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Japan), Discussants: ‌Tetsuya MATSUDA (Tamagawa University, Brain Science Institute, Japan), Masaki FUKUNAGA (Division of Cerebral Integraton, National Institute for Physiological Sciences, Japan)

The ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium is an international effort by leaders worldwide. The Network brings together researchers in imaging genomics, neurology and psychiatry, to understand brain structure and function, based on MRI, DTI, fMRI, genetic data and many patient populations. The ENIGMA Network has several goals: to create a network of like-minded individuals, interested in pushing forward the field of imaging genetics, to ensure promising findings are replicated via member collaborations, in order to satisfy the mandates of most journals, to share ideas, algorithms, data, and information on promising findings or methods, to facilitate training, including workshops and conferences on key methods and emerging directions in imaging genetics. ENIGMA consists of over 30 active working groups (WGs). WGs are organized into four major research cores, sixteen Disease Working groups, six Genomics Groups, four Algorithm Development Groups three Healthy Variation Groups and three Collaborations with Other Consortia. ENIGMA published fifty three papers including review articles and Editorial.
COCORO (Cognitive Genetics Collaborative Research Organization), is the largest collaborative effort in biological psychiatry in Japan. The purpose of COCORO is to elucidate mechanisms of psychiatric disorders and brain function. Researchers in various fields such as neuroscience, molecular biology, genome science, psychiatry, neuroimaging, cognitive science, neurophysiology, psychology, neuropsychopharmacology, gather and exchange pioneer and promote new research fields. The interaction between clinical and basic researchers also facilitate understanding and exchange for translation. COCORO consists of over 30 institutes in Japan and running several projects including neuroimaging, neurophysiology, neurocognition and genetics. COCORO participated more than ten projects of ENIGMA, and also COCORO independently replicated the results of ENIGMA in several projects.
In this symposium, the representative of ENIGMA, Prof. Paul Thompson introduce the outline of ENIGMA. Then, achievement of Disease Working Group in Psychiatric Disorders and Algorithm Development Groups in Diffusion Tensor Imaging will be presented. Lastly, the achievement of COCORO will be presented in conjunction with successful replication of ENIGMA studies and new results. Future collaboration between ENIGMA and COCORO for replication and harmonization each other will be discussed.