AsCNP/JSNP/JSCNP 2019

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[AsCNP] シンポジウム

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[AsCNP_S49] シンポジウム49
Neuroimmune Mechanisms of Mood Disorder: A Translational Perspective

2019年10月13日(日) 10:30 〜 12:10 第6会場 (401+402)

Organizer / Chair: Po See CHEN (Department of Psychiatry, College of Medicine and Hospital , National Cheng Kung University, Taiwan), Co-chair: Yasushi KAJII (T-CiRA Discovery, Takeda Pharmaceutical Company Limited, Japan), Discussants: ‌Masaaki IWATA (Division of Neuropsychiatry, Department of Brain and Neuroscience, Tottori University Faculty of Medicine, Japan), Masahiro OHGIDANI (Department of Neuropsychiatry, Kyushu University, Japan)

Psychosocial adverse conditions involving interpersonal processes are among the strongest proximal risk factors for mood disorders. A biologically plausible, multilevel theory that link experiences of social adverse condition with internal neuroimmune mechanisms that drive pathogenesis for mood disorders has been proposed. Central to this neuroimmune mechanism hypothesis is a novel axis of immune-to-brain bidirectional communication that influences mood and behavior. Under social adverse conditions, sympathetic nervous system can up-regulate myelopoiesis, monocyte trafficking and the expression of pro-inflammatory genes encoding a conserved transcriptional response to adversity (CTRA). The elevated pro-inflammatory cytokines caused by central microglia activation and recruitment of monocytes to the brain contribute to development of mood symptoms such as anhedonia, aggression, psychomotor retardation and social-behavioral withdrawal. Previous studies had suggested that the serum CRP, TNF-alpha levels are to be used as a biomarker for mood status and a predictor of treatment response in mood disorders. Clinical trials that used anti-inflammatory medications as adjunct pharmacotherapy in treating mood disorders. Besides, the neuroimmune mechanisms might link mood disorders with multiple system co-morbidities and sequential dementing change. Insights from this theory may thus shed light on understanding of immune-to-brain bidirectional communications, the rôle of psychosocial adverse conditions, the neuroimmune mechanisms of co-morbidities and late life consequence in mood disorders.

10:30 〜 10:35

Po See CHEN (Department of Psychiatry, College of Medicine and Hospital , National Cheng Kung University, Taiwan)

10:35 〜 10:53

Ya Mei BAI1, 2, 3, Mu Hong CHEN1, 2, 3, Ju Wei HSU1, 2, Kai Lin HUANG1, 2, Pei Chi TU1, 2, 4, 5, Tung-Ping SU3, 6, Cheng Ta LI1, 2, 3, Wei Chen LIN1, 2, 3, Shih Jen TSAI1, 2, 3 (1. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, 2. Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, 3. Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, 4. Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, 5. Institute of Philosophy of Mind and Cognition, National Yang-Ming University, Taipei, Taiwan, 6. Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan)

10:53 〜 11:11

Jane Pei-Chen CHANG1, 2 (1. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK, 2. Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan)

11:29 〜 11:47

Po See CHEN1, Ya-Mei BAI2, Jane Pei-Chen CHANG3, Masahiro OHGIDANI4, Hiroshi KUNUGI5 (1. Department of Psychiatry, College of Medicine, National Cheng Kung University, Taiwan, 2. Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taiwan, 3. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London UK, 4. Department of Neuropsychiatry, , Graduate School of Medical Sciences, Kyushu University, Japan, 5. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan)

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11:47 〜 12:05

Alessandra BORSINI1, Anna NICOLAOU2, Maria Dolores CAMACHO-MUNOZ2, Kuan-Pin SU3, Patricia ZUNSZAIN1, Carmine Maria PARIANTE1 (1Section of Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King’s College London, UK , 2Division of Pharmacy and Optometry, School of Health Sciences and Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Healthy, The University of Manchester, UK, 3Department of Psychiatry & Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital; College of Medicine, China Medical University, Taichung, Taiwan)

12:05 〜 12:10

Ya Mei BAI1, 2, 3 (1. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, 2. Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, 3. Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan)