[AsCNP_S49] シンポジウム49
Neuroimmune Mechanisms of Mood Disorder: A Translational Perspective

2019年10月13日(日) 10:30 〜 12:10 第6会場 (401+402)

Organizer / Chair: Po See CHEN (Department of Psychiatry, College of Medicine and Hospital , National Cheng Kung University, Taiwan), Co-chair: Yasushi KAJII (T-CiRA Discovery, Takeda Pharmaceutical Company Limited, Japan), Discussants: ‌Masaaki IWATA (Division of Neuropsychiatry, Department of Brain and Neuroscience, Tottori University Faculty of Medicine, Japan), Masahiro OHGIDANI (Department of Neuropsychiatry, Kyushu University, Japan)

Psychosocial adverse conditions involving interpersonal processes are among the strongest proximal risk factors for mood disorders. A biologically plausible, multilevel theory that link experiences of social adverse condition with internal neuroimmune mechanisms that drive pathogenesis for mood disorders has been proposed. Central to this neuroimmune mechanism hypothesis is a novel axis of immune-to-brain bidirectional communication that influences mood and behavior. Under social adverse conditions, sympathetic nervous system can up-regulate myelopoiesis, monocyte trafficking and the expression of pro-inflammatory genes encoding a conserved transcriptional response to adversity (CTRA). The elevated pro-inflammatory cytokines caused by central microglia activation and recruitment of monocytes to the brain contribute to development of mood symptoms such as anhedonia, aggression, psychomotor retardation and social-behavioral withdrawal. Previous studies had suggested that the serum CRP, TNF-alpha levels are to be used as a biomarker for mood status and a predictor of treatment response in mood disorders. Clinical trials that used anti-inflammatory medications as adjunct pharmacotherapy in treating mood disorders. Besides, the neuroimmune mechanisms might link mood disorders with multiple system co-morbidities and sequential dementing change. Insights from this theory may thus shed light on understanding of immune-to-brain bidirectional communications, the rôle of psychosocial adverse conditions, the neuroimmune mechanisms of co-morbidities and late life consequence in mood disorders.

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10:30 〜 10:35

[AsCNP-S49-Introduction] Introduction

^○Po See CHEN (Department of Psychiatry, College of Medicine and Hospital , National Cheng Kung University, Taiwan)

10:35 〜 10:53

[AsCNP-S49-1] A comparison study of metabolic, immune and brain grey matter volume between patients with bipolar disorder and depressive disorder

^○Ya Mei BAI^{1, 2, 3}, Mu Hong CHEN^{1, 2, 3}, Ju Wei HSU^{1, 2}, Kai Lin HUANG^{1, 2}, Pei Chi TU^{1, 2, 4, 5}, Tung-Ping SU^{3, 6}, Cheng Ta LI^{1, 2, 3}, Wei Chen LIN^{1, 2, 3}, Shih Jen TSAI^{1, 2, 3} (1. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, 2. Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, 3. Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, 4. Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, 5. Institute of Philosophy of Mind and Cognition, National Yang-Ming University, Taipei, Taiwan, 6. Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan)

10:53 〜 11:11

[AsCNP-S49-2] Omega-3 in mood disorder: Focus on neuroinflammation

^○Jane Pei-Chen CHANG^{1, 2} (1. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK, 2. Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan)

11:11 〜 11:29

[AsCNP-S49-3] Multiple target molecules in the treatment of inflammation-related mood disorders

^○Hiroshi KUNUGI (Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan)

11:29 〜 11:47

[AsCNP-S49-4] Neuroimmune Mechanisms of Mood Disorder: A Translational Perspective

^○Po See CHEN¹, Ya-Mei BAI², Jane Pei-Chen CHANG³, Masahiro OHGIDANI⁴, Hiroshi KUNUGI⁵ (1. Department of Psychiatry, College of Medicine, National Cheng Kung University, Taiwan, 2. Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taiwan, 3. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London UK, 4. Department of Neuropsychiatry, , Graduate School of Medical Sciences, Kyushu University, Japan, 5. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan)

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11:47 〜 12:05

[AsCNP-S49-5] Rescue of cytokines-induced reduction of human neurogenesis and increase in apoptosis by omega-3 fatty acids

^○Alessandra BORSINI¹, Anna NICOLAOU², Maria Dolores CAMACHO-MUNOZ², Kuan-Pin SU³, Patricia ZUNSZAIN¹, Carmine Maria PARIANTE¹ (¹Section of Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King’s College London, UK , ²Division of Pharmacy and Optometry, School of Health Sciences and Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Healthy, The University of Manchester, UK, ³Department of Psychiatry & Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital; College of Medicine, China Medical University, Taichung, Taiwan)

12:05 〜 12:10

[AsCNP-S49-Conclusion] Conclusion

^○Ya Mei BAI^{1, 2, 3} (1. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, 2. Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, 3. Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan)