Academic Events » Symposium

1SBA Protein large-scale motions revealed by quantum beams -a new era in understanding protein dynamics

Wed. Sep 28, 2022 9:00 AM - 11:30 AM Room B (Hakodate Arena Budokan B)

Organizers:Naoki Yamamoto(Jichi Med. Univ.),Hiroshi Sekiguchi(JASRI)

Biological systems function by constantly changing their hierarchical and inter-hierarchical interactions among molecules, cells, and individuals. In order to visualize these dynamics, it is effective to approach them using penetrating quantum beams such as X-rays and neutron beams. This symposium will introduce recent advances in quantum beam techniques for biophysical research, mainly focusing on large structural changes within and between protein molecules. Furthermore, molecular dynamics simulation studies combined with the experimental researches, which deepen the knowledge on molecular mechanisms of the complexed protein systems, will also be shown.

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9:00 AM - 9:03 AM

[1SBA-00] Opening Remarks

9:03 AM - 9:26 AM

[1SBA-1] Allosteric Transition Dynamics in Hemoglobin Reconsidered by Diffracted X-ray Tracking

〇Hiroshi Sekiguchi¹, Naoki Yamamoto², Naoya Shibayama², Yuji Sasaki^1,3 (1.JASRI/SPring-8, 2.Dept. Physiology, Jichi Med. Univ., 3.Grad. Sch. Front. Sci., Univ. Tokyo)

9:26 AM - 9:49 AM

[1SBA-2] Internal dynamics of intrinscially disordered protein as studied by neutron scattering

〇Rintaro Inoue¹ (1.Institute for Integrated Radiation and Nuclear Science, Kyoto University)

9:49 AM - 10:04 AM

[1SBA-3(2Pos050)] Thermodynamic and Molecular Dynamic Analysis of Aromatic Interaction Networks in Protein Cages

〇Yuki Hishikawa¹, Noya Hiroki¹, Asuka Asanuma¹, Basudev Maity¹, Satoru Nagatoishi², Kouhei Tsumoto^2,3, Satoshi Abe¹, Takafumi Ueno¹ (1.Sch. Life Sci. Technol., Tokyo Inst. Technol., 2.Inst. Med. Sci., Univ. Tokyo, 3.Sch. Eng., Univ. Tokyo)

10:04 AM - 10:19 AM

[1SBA-4(1Pos076)] 3D structural determination of proteins from fluctuation X-ray scattering data

〇Wenyang Zhao¹, Osamu Miyashita¹, Florence Tama^1,2 (1.Center for Computational Science, RIKEN, 2.Grad. Sch. Sci., Univ. Nagoya)

10:19 AM - 10:42 AM

[1SBA-5] Microscopic Mechanisms of Stable Amyloid β (1-42) Oligomer Formation

〇IKUO KURISAKI¹, SHIGENORI TANAKA¹ (1.Graduate School of System Informatics, Kobe University)

10:42 AM - 11:05 AM

[1SBA-6] Sub-nanosecond dynamics of amyloid polymorphs and phospholipid molecules observed by incoherent neutron scattering

〇Tatsuhito Matsuo^1,2,3, Alessio De Francesco², Aline Cissé^2,3, Dominique Bicout^2,3, Judith Peters^2,3,4 (1.iQLS, QST, 2.Institut Laue-Langevin, France, 3.Université Grenoble Alpes, France, 4.Institut Universitaire de France)

11:05 AM - 11:28 AM

[1SBA-7] Structural development of amyloid prefibrillar intermediates and its inhibition

〇Naoki Yamamoto¹ (1.Sch. Med. Jichi Med. Univ.)

11:28 AM - 11:30 AM

Session information